During 43 months mean follow-up, 67 patients (25%) died and 4 patients (1%) underwent heart transplantation. CSR during wakefulness was associated with advanced age, atrial fibrillation, decreased LV ejection fraction, increased LV end-diastolic diameter, brain natriuretic peptide, New York Heart Failure class, and CSR during sleep. Primary endpoint during follow-up was heart transplant-free survival.įifty of 267 patients (19%) had CSR during wakefulness and 73 of 267 patients (27%) had CSR during sleep. Prevalence and prognostic significance of CSR during wakefulness in CHF, however, are largely unknown.ĬSR during wakefulness with an apnea-hypopnea cut-off ≥5/h and moderate to severe CSR with an apnea-hypopnea cutoff ≥15/h were analyzed using polysomnographic recordings in 267 patients with stable CHF with reduced left ventricular (LV) ejection fraction at our institution. Cheyne-Stokes respiration (CSR) during sleep has been studied extensively in patients with chronic heart failure (CHF).
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